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目的比较二磷酸果糖和脑活素对新生儿缺血缺氧性脑病的临床疗效。方法将我院2011年1月-2013年1月130例缺血缺氧性脑病患者随机分为FDP组和脑活素组,FDP组给予1,6-二磷酸果糖,脑活素组采用脑活素治疗。观察两组疗效与并发症情况。结果两组治疗后NBNA评分均有显著上升,且FDP组评分高于脑活素组(P<0.05)。FDP组显效率、有效率高于脑活素组。两组均未出现严重并发症,均顺利完成治疗。结论 FDP相较于脑活素对新生儿缺血缺氧性脑病的疗效更佳,值得临床推广。
Objective To compare the clinical effects of fructose diphosphate and cerebrolysin on neonatal hypoxic-ischemic encephalopathy. Methods 130 patients with hypoxic-ischemic encephalopathy in our hospital from January 2011 to January 2013 were randomly divided into FDP group and cerebrolysin group, FDP group was given fructose-1,6-diphosphate, Cerebrolysin group was treated with brain Survivin treatment. The curative effect and complications of the two groups were observed. Results The scores of NBNA in both groups increased significantly after treatment, and the score of FDP group was higher than that of cerebrolysin group (P <0.05). FDP group was markedly efficient and effective than the brain activin group. No serious complications occurred in both groups, and the treatment was successfully completed. Conclusion Compared with cerebrolysin, FDP is more effective in neonatal hypoxic-ischemic encephalopathy and is worthy of clinical application.