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目的:分析抗感染药不良反应发生的情况和原因,为临床安全用药提供参考。方法:对嘉兴市药品不良反应监测中心2007年收集的809例抗感染药不良反应报告进行回顾性分析。结果:引起ADR最多的药物为头孢菌素类,发生率最高的药物是头孢曲松钠;与合并用药有关的ADR占总例数的40.30%,以静脉给药方式为主;ADR的临床表现以皮肤及其附件损害最多见,其次是消化系统和神经系统。结论:加强抗感染药临床合理应用,重视ADR监测工作,保障公众安全用药。
Objective: To analyze the situation and causes of adverse reactions of anti-infectives and provide reference for clinical safety medication. Methods: A retrospective analysis of 809 anti-infective drug adverse reactions reported by Jiaxing ADR Monitoring Center in 2007 was conducted. Results: The drug with the most ADR was cephalosporins and the drug with the highest incidence was ceftriaxone sodium. The ADR associated with drug combination accounted for 40.30% of the total cases, mainly by intravenous administration. The clinical manifestations of ADR Damage to the skin and its attachments the most common, followed by the digestive system and the nervous system. Conclusion: To strengthen the clinical application of anti-infectives, pay attention to ADR monitoring and ensure public safety medication.