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目的分析16例因外用黄丹粉所致的高铅血症、铅中毒婴幼儿的临床表现及血锌、钙、铁、铜、镁变化的意义。方法采用原子吸收法检测16例外用黄丹粉儿童的全血微量元素水平,并进行高血铅诊断分级;对其临床症状以及低锌、低钙、低铁发生情况进行分析。对16例儿童均停用黄丹粉,并给予锌、钙和(或)铁及多种维生素制剂等综合治疗。结果16例儿童中高铅血症、轻度铅中毒、中度铅中毒分别占62.50%、12.50%和25.00%,无重度铅中毒;纳差、贫血、生长迟缓、低锌、低钙和低铁发生率分别为87.50%、43.75%、37.50%、37.50%、18.75%和37.50%,血铜、镁无变化;16例儿童血铅分别于治疗2～4个月降至正常水平,临床症状改善,血锌、钙、铁水平恢复正常。结论外用黄丹粉可导致婴幼儿高铅血症,甚至铅中毒,应加强健康教育;采用锌、钙和(或)铁及多种维生素等治疗,可取得较好效果。
Objective To analyze the clinical manifestations and changes of blood zinc, calcium, iron, copper and magnesium in 16 cases of lead-induced hyperlipidemia and lead poisoning caused by topical Huangdan powder. Methods The level of trace elements in whole blood of 16 children with Huangdan powder was detected by atomic absorption spectrometry, and the blood lead level was diagnosed and graded. The clinical symptoms and the occurrence of low zinc, low calcium and low iron were analyzed. 16 cases of children were disabled yellow powder, and given zinc, calcium and (or) iron and a variety of vitamin preparations and other comprehensive treatment. Results There was no severe lead poisoning in 62 children with moderate or severe lead poisoning, mild lead poisoning and moderate lead poisoning, accounting for 62.50%, 12.50% and 25.00% respectively. Anorexia, anemia, growth retardation, low zinc, low calcium and low iron The incidence rates of blood copper and magnesium were unchanged in 87.50%, 43.75%, 37.50%, 37.50%, 18.75% and 37.50% respectively. The blood lead levels of 16 children were reduced to normal levels after 2 to 4 months of treatment and the clinical symptoms were improved , Blood zinc, calcium, iron levels returned to normal. Conclusion Topical Huangdan powder can lead to hyperlipidemia and even lead poisoning in infants and young children. Health education should be strengthened. Treatment with zinc, calcium and / or iron and various vitamins can achieve better results.