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[目的]探讨美沙拉嗪联合丹参注射液治疗溃疡性结肠炎(UC)的疗效及对患者炎性因子与凝血指标的影响。[方法]选取我院2014年7月~2015年7月符合入选标准的UC患者120例,随机分为对照组和观察组,每组60例;对照组给予美沙拉嗪肠溶片治疗,观察组在对照组给药的基础上加用丹参注射液静滴治疗,疗程均为30d,治疗结束后比较2组患者临床疗效、炎性因子及凝血指标。[结果]经过治疗,观察组患者的临床有效率明显高于对照组,复发率低于对照组,差异有统计学意义(P<0.05);治疗后2组患者的TNF-α、IL-6及IL-8等3种炎性因子水平较治疗前均有不同程度的下降;与对照组相比,观察组患者上述3种炎性因子水平下降显著,差异有统计学意义(P<0.05);治疗后2组患者的FIB、PLT及MPV水平较治疗前均有不同程度的变化;与对照组比较,观察组患者FIB和PLT水平下降显著,MPV水平增加显著,差异有统计学意义(P<0.05);治疗期间,2组患者均观察到不良反应,但程度轻微。[结论]美沙拉嗪联合丹参注射液能减轻UC患者炎性反应,降低血液高凝状态,提高临床治疗效果,且不良反应轻微,值得在临床上进一步研究及推广使用。
[Objective] To investigate the curative effect of mesalazine and Salvia miltiorrhiza injection on ulcerative colitis (UC) and its influence on inflammatory factors and coagulation indexes in patients. [Methods] A total of 120 UC patients who met the inclusion criteria from July 2014 to July 2015 in our hospital were randomly divided into control group and observation group, 60 cases in each group. The control group was treated with mesalazine enteric-coated tablets and observed The rats in the control group were given intravenous infusion of Danshen injection for 30 days. After the treatment, the clinical efficacy, inflammatory factors and coagulation indexes were compared between the two groups. [Result] After treatment, the clinical effective rate in the observation group was significantly higher than that in the control group, the recurrence rate was lower than that in the control group, the difference was statistically significant (P <0.05); after treatment, the levels of TNF-α and IL-6 (P <0.05). Compared with the control group, the level of inflammatory cytokines in the observation group decreased significantly (P <0.05) ; After treatment, the levels of FIB, PLT and MPV in both groups changed to some extent compared with that before treatment; compared with the control group, the levels of FIB and PLT decreased significantly in the observation group and the levels of MPV increased significantly (P <0.05). During treatment, adverse reactions were observed in both groups, but to a lesser extent. [Conclusion] Mesalazine combined with Salvia miltiorrhiza injection can relieve the inflammatory reaction, reduce the blood hypercoagulability and improve the clinical curative effect in patients with UC, and the adverse reaction is slight, so it is worth further research and popularization in the clinical application.