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３０只家兔随机等分为三七组、对照组和正常组，用甘油复制ＡＴＮ模型，三七组兔于注射甘油后即刻、第３和第６小时分别肌注三七皂甙，观察２４ｈ肾脏生化和形态学改变。结果发现，三七组动物血清肌酐、尿素氮、滤过钠排泄分数和尿总氨基酸明显低于对照组，而动物存活率、尿渗透压明显高于对照组（Ｐ＜０．０５～Ｐ＜０．０１），肾组织损伤程度也明显减轻，说明三七皂甙可改善甘油所致ＡＴＮ的肾功能，减轻肾小管变性坏死，其机理可能与其减少氧自由基损伤，保护抗氧化酶和ＡＴＰ酶，减轻钙超载有关
Thirty rabbits were randomly divided into three groups, the control group and the normal group, with ATN model of glycerol replication, three groups of rabbits immediately after injection of glycerol, 3 and 6 hours intramuscular notoginseng saponins were observed 24h kidney Biochemical and morphological changes. The results showed that serum creatinine, urea nitrogen, filtration sodium excretion and urine total amino acids in the panax notoginseng group were significantly lower than those in the control group, while animal survival rate and urine osmolality were significantly higher than those in the control group (P <0.05 ~ P < 0.01). The injury degree of renal tissue was also significantly reduced, indicating that Panax Notoginseng Saponins could improve the renal function of ATN induced by glycerol and reduce the renal tubular degeneration and necrosis. The mechanism may be related to reducing the damage of oxygen free radicals and protecting the antioxidase and ATPase , Reduce calcium overload