自deBold 1981年首先发现心房利钠激素以来,利钠激素研究已有很大进展。特别是应用分子生物学技术研究利钠激素的组织特异性表达、基因转录调控和转基因动物模型等,使得人们对利钠激素的认识从循环内分泌角度深入到细胞分子水平,转而强调其组 Since deBold’s first discovery of atrial natriuretic hormone in 1981, there has been considerable progress in natriuretic hormone research. In particular, the use of molecular biology techniques to study the tissue-specific expression of sodium natriuretic hormone, gene transcription regulation and transgenic animal models, etc., making people’s understanding of natriuretic hormone from the perspective of circulating endocrine into the molecular level of cells, instead emphasizing its group