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卵胞质内单精子注射技术(ICSI)使严重少弱精子症及梗阻性无精子症患者获得生育其遗传学子代成为可能。但ICSI后受精胚胎的质量和植入率仍不理想且人为选择的精子不能确保其子代的安全。选择何种精子进行ICSI,能否改善胚胎质量,降低子代风险等已成为现今研究的热点。各国学者分别从受精的关键、影响受精的因素以及ICSI治疗不育症的潜在风险等多方面进行研究。
Intracytoplasmic sperm injection (ICSI) makes it possible for children with severe oligozoospermia and obstructive azoospermia to get their genetic offspring. However, the quality and implantation rate of fertilized embryos after ICSI is still not ideal and artificially selected sperm can not ensure the safety of their offspring. It has become a hot research topic today to choose which kind of sperm to carry out ICSI, whether to improve embryo quality and reduce the risk of offspring. Scholars from various countries study the key factors of fertilization, the factors that affect fertilization and the potential risks of ICSI treatment of infertility.