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目的 探讨丽珠肠乐对肝硬化顽固性腹水并发菌群失调的治疗作用。方法 选择住院治疗肝硬化顽固性腹水病人67例,在基础支持疗法和护肝、利尿、抗感染治疗基础上,按入院顺序分为丽珠肠乐治疗组(35例)和乳果糖组(32例),观察治疗前、后病人的腹水、生化、血氨、血浆内毒素等的变化。结果 丽珠肠乐组和乳果糖组67例病人治疗后病情有不同程度的缓解,腹水消失或减少,生化指标改善,血氨和血浆内毒素水平明显降低,与治疗前比较,分别有极其显著的差异(P<0.01)。两组治疗后比较,丽珠肠乐组降低血氨和内毒素的作用明显优于乳果糖组,分别有极其显著的差异(P<0.01)。6例原发性腹膜炎病人也取得较好疗效。结论 丽珠肠乐对肝硬化顽固性腹水病人合并胃肠功能紊乱和菌群失调的治疗有明显的辅助治疗作用。可有效纠正肝硬化顽固性腹水病人的球茵/杆菌比例失调,通畅大便和排气,减轻病人腹胀症状,降低血氨和血浆内毒素,防止发生其它并发症。
Objective To investigate the therapeutic effect of Lizhuchangle on dysbacteriosis of cirrhosis complicated with ascites. Methods Sixty-seven inpatients with cirrhosis and refractory ascites were enrolled in this study. Based on the basic supportive therapy and hepatoprotective, diuretic and anti-infective therapy, they were divided into three groups according to admission sequence: Cases), observed before and after treatment of patients with ascites, biochemical, blood ammonia, plasma endotoxin and other changes. Results 67 cases of Lixue Changle and lactulose patients had different degrees of relief after treatment, the ascites disappeared or decreased, the biochemical indexes improved, the levels of serum ammonia and plasma endotoxin were significantly lower than those before treatment, which were extremely significant (P <0.01). After treatment, the effect of reducing blood ammonia and endotoxin in Ligustrum group was significantly better than those in lactulose group, with significant differences (P <0.01). Six patients with primary peritonitis also achieved better results. Conclusions Lizhu Renle has a significant adjuvant therapeutic effect on the treatment of patients with cirrhosis and refractory ascites complicated with gastrointestinal dysfunction and flora. Can effectively correct the liver cirrhosis patients with refractory ascites / bacteria imbalance, smooth stool and exhaust, reduce symptoms of bloating, reduce blood ammonia and plasma endotoxin, to prevent the occurrence of other complications.