本文报道22个4-硝基二苯胺-4′-硫代氨基甲酸衍生物和其二苯醚二苯硫醚类似物的合成,大多数化合物为氨基甲(?)酸芳酯。筛选结果表明4-硝基二苯胺-4′-氨基甲(?)酸芳酯和二苯醚类似物有较强的抗日本血吸虫作用而二苯硫醚类似物则无明显的抗虫作用。4-硝基二苯胺-4′-氨基甲(?)酸苯酯——硝硫苯酯(代号7720)已作为抗日本血吸虫病药物在临床试用,证明其疗效较高,毒性较低。本文还简要讨论了结构和抗日本血吸虫作用的关系。 This paper reports the synthesis of 22 4-nitrodiphenylamine-4’-thiocarbamic acid derivatives and their diphenylether diphenyl sulfide analogues, most of which are the aryl aryl carbamates. Screening results showed that 4-nitrodiphenylamine-4’-aminomethyl (?) Acid aryl ester and diphenyl ether analogues have strong anti-Schistosoma japonicum effect while diphenyl sulfide analogs have no obvious anti-insect effect. 4-Nitrodiphenylamine-4’-aminophenyl (?) - nitrophenyl ester (code 7720) has been used clinically as an anti-schistosomiasis drug, demonstrating its efficacy and toxicity. This article also briefly discussed the structure and anti-Schistosoma japonicum role.