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Objective:To investigate antidiabetic potential of alcoholic leaves extract of Alangium lamarekii (A.lamarckii) on streptozotocin-nicotinamide induced type 2 diabetic rats.Methods:Oral glucose tolerance test was done by inducing hyperglycemic state via administration of glucose in water(2 g/kg).Single dose of alcoholic leaves extract of.4.lamarckii(250 and 500 mg/kg,p.o.) were administered to normoglycemic,hyperglycemic rats.Type 2 diabetes was induced by single intraperitoneal injection of nicotinamide(110 mg/kg) followed by streptozotocin(65 mg/kg).The study also included estimations of blood plasma glucose,lipid profile,liver glycogen,body weight and antioxidant status in normal and diabetic rats.Results:Admistration of alcoholic extract of A.lamarekii at two dosage 250 and 500 rag/kg,p.o.did not showed any significant change in blood glucose level of normoglycemic rats(P>0.05).whereas,oral glucose tolerance test depicted reduction in blood glucose level(P<0.05).The streptozotocin-nicotinamide induced diabetic rats, significantly decreased the blood plasma glucose level(P<0.001) comparable to glibenclamide (10 mg/kg),restored the lipid profile and showed improvement in liver glycogen,body weight and antioxidant status in diabetic rats.Conclusions:Present finding demonstrated the significant antidiabetic activity of alcoholic leaves extract of.4.lamarekii.
Objective: To investigate antidiabetic potential of alcoholic leaves extract of A. lamarckii on streptozotocin-nicotinamide induced type 2 diabetic rats. Methods: Oral glucose tolerance test was done by inducing hyperglycemic state via administration of glucose in water (2 g / kg). Single dose of alcoholic leaves extract of 4.lamarckii (250 and 500 mg / kg, po) were administered to normoglycemic, hyperglycemic rats. Type 2 diabetes was induced by single intraperitoneal injection of nicotinamide (110 mg / kg) by streptozotocin (65 mg / kg) .The study also includes estimations of blood plasma glucose, lipid profile, liver glycogen, body weight and antioxidant status in normal and diabetic rats. Results: Admistration of alcoholic extract of A.lamarekii at two dosage 250 , and 500 rag / kg, podid not showed any significant change in blood glucose level of normoglycemic rats (P> 0.05). Whereas, oral glucose tolerance test was carried out in blood glucose level (P <0.05). streptozotocin-n The decreased lipid plasma glucose level (P <0.001) comparable to glibenclamide (10 mg / kg), restored the lipid profile and showed improvement in liver glycogen, body weight and antioxidant status in diabetic rats. Conclusions: Present finding demonstrated the significant antidiabetic activity of alcoholic leaves extract of.4.lamarekii.