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庚炔诺酮(NET-OEN)与长效甲孕酮(DMPA)均在英国合法应用。NET-OEN的研究不如DMPA广泛。作者应用了7年,本文总结1974～1981年的临床经验。 NET-OEN是一种长效油剂肌注避孕针,每ml含200mgNET-OEN,707例妇女中,应用了9,024个妇女月。研究期共分两个阶段:第一阶段(1974.3.1～1978.3.1),观察了324例病人,第二阶段(1978.4.1～1981.3.1),另外观察了383例,研究了药代动力学、药效学、效果、注射间隔天数、副反应和继续使用率。前三年注射间隔为70±17天(10周),1977年3月改为56±7天(8
NET-OEN and DMPA are all legally validated in the United Kingdom. NET-OEN research is not as extensive as DMPA. The authors applied for seven years, this article summarizes the clinical experience of 1974 ~ 1981. NET-OEN is a long-acting oil intramuscular injectable needle that contains 200 mg ofNET-OEN per ml and used 9,024 women’s months out of 707 women. The study period was divided into two phases: the first phase (1974.3.1 ~ 1978.3.1), 324 patients were observed, the second phase (1978.4.1 ~ 1981.3.1), another 383 cases were observed, the pharmacokinetics Kinetics, Pharmacodynamics, Effects, Days Between Injections, Side Effects, and Continued Use. The first three years of injection interval of 70 ± 17 days (10 weeks), March 1977 changed to 56 ± 7 days (8