局限性硬皮病是临床常见的疾病,它是以血管狭窄、缺血缺氧,局限性皮肤结缔组织的纤维化或硬化,最后发生萎缩为特点的疾病。目前,病因不明。过去认为免疫学说,胶原纤维合成异常学说及血管学说,近年国外文献报导,局限性硬皮病与色氮酸代谢紊乱等因素有关,我科从1989年开始研究用中西药并低频电疗治疗局限性硬皮病,在治疗中发现局限性硬皮病与维生素B_6缺乏有一定的关系,为探讨发病机理,现将这方面的研究进展作简要综述。 1 维生素B_6与色氨酸的关系 色氨酸是人体一种必需氨基酸,其主要代谢途径有二条。在代谢过程中与维生素B_1、B_2、B_5、B_6有密切关系。 1.1 经色氨酸羟化酶作用代谢为5-羟色氨酸,再进一步经5 Limitations Scleroderma is a common clinical disease, which is characterized by vascular stenosis, ischemia and hypoxia, localized connective tissue fibrosis or sclerosis, and finally the occurrence of atrophy. At present, the cause is unknown. In the past that the immune theory, abnormal collagen synthesis theory and vascular theory that foreign literature in recent years, the limitations of scleroderma and metabolic disorders and other factors related to color, our department from 1989 to study the treatment of traditional Chinese and Western medicine and low-frequency electrosurgery limitations Scleroderma, found in the treatment of localized scleroderma and vitamin B_6 deficiency has a certain relationship, in order to explore the pathogenesis, the research progress in this area are briefly reviewed. 1 vitamin B_6 and the relationship between tryptophan Tryptophan is an essential amino acid, the main metabolic pathways have two. In the metabolic process with vitamin B_1, B_2, B_5, B_6 are closely related. 1.1 by the role of tryptophan hydroxylase metabolism of 5-hydroxytryptophan, further by 5