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目的:观察中医健腹操加药茶对代谢综合征(MS)患者胰岛素抵抗(IR)及胰岛β细胞水平的影响。方法:根据2005年国际糖尿病联盟关于MS定义的全球共识的标准,选择新诊断MS患者160例,采用病例自身对照方法,给予中医健腹操加药茶治疗8周,观察治疗前后空腹血糖、空腹胰岛素、胰岛素抵抗指数(HOMA—IR)、胰岛β细胞功能指数(HOMA-β)水平变化。结果:治疗8周后,MS患者的空腹血糖、空腹胰岛素水平明显降低,与治疗前相比均有统计学意义(均P<0.05),MS患者的HOMA—IR显著降低,分别为(6.35±1.63)和(4.29±1.53),(P<0.01);MS患者的HOMA-β水平水平显著提高,分别为(92.69±15.36)和(120.89±16.92),(P<0.01)。结论:中医健腹操加药茶能改善代谢综合征患者的空腹血糖、空腹胰岛素等临床指标,减轻腹部肥胖,改善胰岛素抵抗,提高胰岛β细胞功能,改善患者生活质量。
Objective: To observe the effects of Chinese herbal medicine plus abdominal plus herbal tea on insulin resistance (IR) and pancreatic β-cell level in patients with metabolic syndrome (MS). Methods: According to the 2005 International Diabetes Federation definition of the definition of MS on the basis of the global consensus criteria, the selection of 160 cases of newly diagnosed MS patients, the case of self-control method, giving herbalist abdominal plus herbal tea for 8 weeks, observed fasting blood glucose before and after treatment, fasting Insulin, insulin resistance index (HOMA-IR) and pancreatic β-cell function index (HOMA-β). Results: After 8 weeks of treatment, the fasting blood glucose and fasting insulin levels in MS patients were significantly lower than those before treatment (all P <0.05), while the levels of HOMA-IR in MS patients were significantly lower (6.35 ± 1.63 and 4.29 ± 1.53, respectively (P <0.01). The levels of HOMA-β in MS patients were significantly higher than those in MS patients (92.69 ± 15.36 and 120.89 ± 16.92, respectively, P <0.01). Conclusion: Herbal Supplementation plus Herbal Tea can improve clinical indicators such as fasting blood glucose and fasting insulin in patients with metabolic syndrome, reduce abdominal obesity, improve insulin resistance, improve pancreatic β-cell function and improve quality of life of patients.