本文对作为防老剂和稳定剂的亚磷酸三苯酯进行了急性、亚急性和慢性毒性研究。实验结果表明,当给动物经口注入亚磷酸三苯酯后,立刻出现兴奋、躁动,然后出现抑制、步态不稳、震颤、阵挛性和强直性痉挛。多数动物于24小时内死亡。病理组织学检查发现,内脏和大脑有毛细血管扩张、水肿和出血,周围神经出现不同程度退行性变。小鼠LD_(50)为1,360.0 In this paper, acute, subacute and chronic toxicity studies of triphenylphosphite as an antioxidant and stabilizer were carried out. The experimental results show that when animals are injected with triphenylphosphite orally, there is excitement and restlessness immediately followed by inhibition, unsteady gait, tremor, clonic and tonic spasms. Most animals die within 24 hours. Histopathological examination revealed that the viscera and brain have telangiectasias, edema and hemorrhage, and peripheral nerves degenerate to varying degrees. Mouse LD_ (50) was 1,360.0