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目的 :观察分析 SL E13项诊断标准对儿童系统性红斑狼疮 ( SL E)临床诊断的意义.方法 :回顾性总结 10 4例儿童 SL E的临床资料.结果 :110 4例儿童患者的症状、体征和实验室检查 ,阳性率最高的项目依次为免疫荧光法抗核抗体 ( IFANA)阳性 ( 90 .1%)、蛋白尿或管型尿或血尿 ( 83 .6%)、补体 C3降低 ( 75 .0%)、非畸形性关节炎或多关节痛 ( 5 9.6%)、抗双链脱氧核糖核酸 (抗 DS DNA)抗体阳性或狼疮细胞 ( L E细胞 )现象 ( 5 2 .8%)、蝶形红斑或盘状红斑 ( 4 6.2%) (其中盘状红斑仅 1例 ). 2符合 5~ 8项诊断标准的例数分别为 65、 4 8、 2 8、 11例.3最常见的 6项组合为蝶形红斑或盘状红斑、非畸形性关节炎或多关节痛、蛋白尿或管型尿或血尿、IFANA阳性、抗DS DNA阳性或 L E细胞现象、C3降低.结论 :SL E的诊断标准适用于儿童“,”Objective:To evaluate the diagnosis criteria for childhood systemic lupus erythematosus(SLE) Methods:Clinical data of 104 SLE patients were reviewed Results:①The incidence of positive immunofluorescence antinuclear antibody(IFANA),abnormal urine examination,depressed C3 level,arthritis,positive anti dsDNA/lupus erythematosus(LE)cells and butterfy/discoid rash were 90 1%,83 6%,75 0%,59 6%,52 8%,and 46 2%,respectively ②The number of cases meeting 5~8 criteria was 65,48,28,and 11 respectively ③The most common combination of six clinical findings included positive IFANA,abnormal urine examination,depressed C3 level,arthritis,positive anti dsDNA/LE cells and butterfy/discoid rash Conclusions:The critieria for diagnosis of SLE may be applicable for childhood SLE