急性肾功能衰竭初期肾血流量下降和肾内血流分配异常明显存在,一些肾内体液因素,持别是前列腺素系统,介导这种血流动力异常变化。血管活性药物PGE_2、PGI_2、可乐宁、异搏定等用于该疾病防治,在动物模型上已初步显示有良好效果,目前尚缺乏临床的观察资料。 In the early stage of acute renal failure, the decrease of renal blood flow and the abnormal distribution of renal blood flow obviously exist. Some intrarenal fluid factors, which are different from the prostaglandin system, mediate this abnormal change of hemodynamics. Vascular active drugs PGE_2, PGI_2, Clonidine, Verapamil for the prevention and treatment of the disease, the animal model has initially shown to have good results, the current lack of clinical observation data.