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晶体生长机制的研究是实现结晶过程控制尤其是以溶液为媒介的多晶型转换过程控制的关键。本研究利用经验模型研究了盐酸帕罗西汀的晶体生长机制。结果表明,随温度的升高,初级成核速率升高,而固液界面张力却存在微弱下降趋势;晶体生长机制为表面反应控制;晶体生长属于与粒度或体积无关的连续生长模式。
The study of crystal growth mechanism is the key to control the crystallization process, especially the solution-mediated polymorphic conversion process. In this study, we used empirical models to study the crystal growth mechanism of paroxetine hydrochloride. The results show that the initial nucleation rate increases with the increase of temperature, while the interfacial tension decreases slightly. The crystal growth mechanism is controlled by surface reaction. The crystal growth belongs to continuous growth mode which has no relation with particle size or volume.