目的:观察结肠宁对溃疡性结肠炎模型大鼠的抗炎镇痛作用。方法:乙酸法建立溃疡性结肠炎动物模型,灌肠给予结肠宁混悬液7 d,以体征变化、结肠病理学组织变化为指标观察结肠宁的治疗效果。以大鼠肉芽肿模型以及热板法考察结肠宁的抗炎镇痛作用。结果:灌肠给药结肠宁治疗后,溃疡性结肠炎大鼠体征转好,结肠黏膜溃疡及糜烂病灶已见愈合瘢痕,杯状细胞较丰富,淋巴细胞轻度浸润,其基本形态与正常组相似。大鼠肉芽肿质量增加以及痛阈均与模型组有显著性差异,与阳性对照组无显著性差异。结论:结肠宁对溃疡性结肠炎有较好的治疗抗炎镇痛作用。 Objective: To observe the anti-inflammatory and analgesic effect of colicin on ulcerative colitis model rats. Methods: The animal model of ulcerative colitis was established by acetic acid method. Colon-ningling suspension was administered for 7 days by enema. The therapeutic effect of colorectal cancer was observed with the changes of signs and histopathological changes. Anti-inflammatory and analgesic effects of colonic-ning in rats were induced by rat granuloma model and hot-plate method. Results: After the enema was administered to colorectal, the symptoms of ulcerative colitis rats turned better, the mucosal ulcer and erosive lesions had healed scar, the goblet cells were abundant and the lymphocytes were slightly infiltrated. The basic morphology was similar to the normal group . Rat granuloma mass and pain threshold increased with the model group had significant differences, and the positive control group no significant difference. Conclusion: Colonum has better anti-inflammatory and analgesic effects on ulcerative colitis.