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目的 :探讨一氧化氮 (NO)、肿瘤坏死因子 (TNF -α)及内皮素 (ET)与脑卒中的相关关系及其临床意义。方法 :采用特异性放射免疫法和硝酸还原酶法测定 10 4例脑卒中 (急性脑梗死、急性脑出血各 5 2例 )患者及 5 0例健康人的外因血TNF -α、ET、NO的含量。结果 :急性脑卒中患者血清NO含量明显低于对照组 ,而TNF -α、ET含量则显著高于对照组 ,并随病情的稳定与好转发生变化。结论 :NO、TNF -α、ET可能参与脑卒中的疾病发展、演变过程 ,可作为判断脑卒中病情轻重和估计预后的一种参考指标。
Objective: To investigate the relationship between nitric oxide (NO), tumor necrosis factor (TNF-α) and endothelin (ET) and stroke and its clinical significance. Methods: Totally 104 patients with stroke (acute cerebral infarction, 52 with acute intracerebral hemorrhage) and 50 healthy controls were enrolled in this study. The levels of TNF-α, ET and NO were determined by specific radioimmunoassay and nitrate reductase assay content. Results: The serum NO level in patients with acute stroke was significantly lower than that in the control group, while the levels of TNF-α and ET were significantly higher than those in the control group, and the changes were stable and improved. Conclusion: NO, TNF-α and ET may participate in the development and evolution of the disease in stroke, which can be used as a reference index to judge the severity of stroke and estimate the prognosis.