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目的探讨高危型人乳头状瘤病毒感染与乳腺癌临床及病理特点方面的相关性。方法2008年5月至11月山东大学齐鲁医院乳腺外科采集经病理证实的85例乳腺癌及20例乳腺良性病变的活组织标本,采用二代杂交捕获试验(HC2)进行HPVDNA检测,同时检测雌激素受体(ER)、孕激素受体(PR)及Her-2基因表达情况。结果85例乳腺癌样本中,高危型人乳头状瘤病毒阳性率为30.6%(26/85);与良性病变组(阳性率为0)差异有统计学意义(P=0.01);40岁以下乳腺癌病人HR-HPV阳性率为69.2%(9/13),明显高于40岁以上病人(23.6%,17/72,P=0.027);HR-HPV阳性率在不同临床及病理学特点的乳腺癌中差异没有统计学意义。结论乳腺癌组织中确实存在HR-HPV感染,HR-HPV在乳腺癌的发病过程中可能起着重要作用。
Objective To investigate the relationship between high-risk human papilloma virus infection and clinical and pathological features of breast cancer. Methods 85 cases of pathologically confirmed breast cancer and 20 cases of breast benign lesion were collected from Department of Breast Surgery, Qilu Hospital of Shandong University from May 2008 to November. The second generation hybridization capture test (HC2) Hormone receptor (ER), progesterone receptor (PR) and Her-2 gene expression. Results The positive rate of high-risk human papillomavirus was 30.6% (26/85) in 85 cases of breast cancer samples, and the difference was statistically significant (P = 0.01) The positive rate of HR-HPV in breast cancer patients was 69.2% (9/13), significantly higher than those over 40 years old (23.6%, 17/72, P = 0.027). The positive rate of HR-HPV in different clinical and pathological features The difference in breast cancer was not statistically significant. Conclusion HR-HPV infection does exist in breast cancer tissues. HR-HPV may play an important role in the pathogenesis of breast cancer.