论文部分内容阅读
目的 :观察美施康定、路泰对重度癌痛的止痛效果及对患者生活质量的影响。方法 :1 45例经病理证实的中晚期重度癌痛病人 ,83例服用美施康定 (A组 ) ,6 2例服用路泰 (B组 ) ,初始剂量均为 30mg口服 ,每 1 2h一次 ;据实际疗效来调整用量 ,每次递增 30mg ,直到达到满意的止痛效果。结果 :美施康定、路泰的镇痛有效率分别为 :95 .2 % ,93.5 %。完全缓解率分别为 81 .9% ,80 .6 %。镇痛有效时间分别为 :9.1±4.1h ,8.7± 4.4h。两药镇痛效果及镇痛有效时间经统计学处理无显著性差异 (P >0 .0 5 )。治疗后分别有 6 2人 ( 74.7% ) ,47人 ( 75 .8% )生活质量较前提高一个等级 ,治疗前后患者生活质量存在着显著性差异 (P <0 .0 1 )。两药对骨痛、内脏痛、软组织浸润痛效果好 ,对神经痛效果欠佳。神经痛与其它类型疼痛的镇痛效果存在着显著性差异 (P <0 .0 1 )。两药的主要不良反应均为便秘 ,恶心、呕吐、嗜睡、排尿困难等。结论 :美施康定或路泰对重度癌痛止痛效果好 ,镇痛时间长 ,副作用小 ,改善了患者的生活质量 ,可作为治疗重度癌痛的首选药物
OBJECTIVE: To observe the analgesic effect of Meishen Kangding and Luotai on severe cancer pain and its impact on the quality of life of patients. Methods: One hundred and forty-five patients with moderate to advanced severe cancer pain confirmed by pathology were enrolled in this study. 83 cases were given AstraZeneca (group A) and 62 cases were treated with LuTai (group B). The initial dose was 30 mg orally every 12 hours. According to the actual effect to adjust the dosage, each increment of 30mg, until a satisfactory analgesic effect. Result: The effective rates of analgesia of Meishi Kangding and Lutet were 95.2% and 93.5% respectively. The complete remission rates were 81.9% and 80.6% respectively. Analgesic effective time was: 9.1 ± 4.1h, 8.7 ± 4.4h. The analgesic effect and analgesic effective time of the two drugs showed no significant difference by statistical analysis (P> 0.05). After treatment, 62 (74.7%) and 47 (75.8%) patients, respectively, had a higher quality of life than those before. There was a significant difference in quality of life before and after treatment (P <0.01). Two drugs on bone pain, visceral pain, soft tissue infiltration pain effect, poor efficacy of neuralgia. Neuropathic pain and other types of pain analgesic effect there is a significant difference (P <0. The two major adverse reactions are constipation, nausea, vomiting, lethargy, dysuria and so on. Conclusion: Meishenkangding or Lutet has good analgesic effect on severe cancer pain, long analgesic time and small side effects, which can improve the quality of life of patients and can be used as the drug of choice for treating severe cancer pain