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目的:研究S波段高功率微波 (HPM)对家兔眼的损伤效应。方法:家兔在散瞳麻醉只暴露头部的条件下,分 3个剂量水平,单次HPM远场平面波照射,于照后 7个时间点,通过肉眼、眼底镜、裂隙灯观察,以及视网膜电图测定、组织病理学方法等研究HPM对家兔的角膜、晶状体、视网膜等眼重要部位的结构与功能的影响。结果:HPM照射后,角膜表面粗糙,一周内恢复;晶状体后皮质出现点状混浊斑,逐渐发展为片状;视网膜组织病理切片观察到弥漫性视网膜损伤,视乳头下方视敏感区损伤重,其他部位较轻,感光细胞的内外节层以及外核层均有不同程度的病理改变;视网膜电图b波幅值降低说明视网膜功能下降。结论:单次HPM照射兔眼 (平均功率密度≥60mW/cm2,照射时间≥30min),可导致眼结构和功能的损伤,损伤程度呈现一定剂量相关性。
Objective: To study the damage effect of S-band high power microwave (HPM) on rabbit eyes. Methods: Rabbits under dilated anesthesia only exposed the head, divided into three dose levels, a single HPM far-field plane wave irradiation, 7 points after irradiation, by the naked eye, fundus, slit lamp observation, and the retina Electrocardiogram and histopathology were used to study the effect of HPM on the structure and function of important ocular parts such as cornea, lens and retina in rabbits. Results: After corneal HPM irradiation, the surface of the cornea was rough and recovered in one week. The ophthalmic spot appeared cloudy in the lens and gradually developed into flake. The diffuse retinal injury was observed in the histopathological retina, The site is lighter, the photoreceptor cell inner and outer layers as well as the outer nuclear layer have different degrees of pathological changes; retinal b wave amplitude decreased retinal function decline. CONCLUSION: Rabbit eye (average power density≥60mW / cm2, irradiation time≥30min) with a single HPM irradiation can lead to damage of eye structure and function, with a dose-dependent degree of injury.