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在几种动物模型上观察了四丙酰关附醇胺（ＴＰＧＦＡ）的抗心律失常作用．ＴＰＧＦＡ使引发室性早搏，室性心动过速和心室纤颤所需乌头碱用量增加５０％的剂量分别为１．６，１．４ＦＫ和１．８ｍｇ·ｋｇ－１；ＴＰＧＦＡ２ｍｇ·ｋｇ－１可提高豚鼠心脏毒毛花苷Ｇ中毒的耐受量和家兔心脏电致室颤阈；ＴＰＧＦＡ还降低Ｃａ－Ｃｌ２诱发的大鼠室颤发生率和死亡率，以及麻醉大鼠心脏冠脉结扎—再灌性室性心动过速和室颤的发生率．ＴＰＧＦＡ的上述抗心律失常作用较关附甲素强．ＴＰＧ－ＦＡ显著延长大鼠心电图的ＱＴｃ间期，而对Ｐ－Ｒ间期和ＱＲＳ时程影响不明显．小鼠ｉｖＴＰＧＦＡ的ＬＤ５０为４２ｍｇ·ｋｇ－１．
The anti-arrhythmic effects of tetrapropionyl-ethanolamine (TPGFA) were observed on several animal models. The doses of TPGFA that increased 50% of the aconitine required for premature ventricular premature ventricular tachycardia, ventricular tachycardia and ventricular fibrillation were 1.6, 1.4FK and 1.8 mg · kg-1, respectively. TPGFA 2 mg · kg -1 Can increase the tolerance of guinea pig heart glycosides G poisoning and rabbit cardiac electrical ventricular fibrillation threshold; TPGFA also reduces the Ca-Cl2 induced rat ventricular fibrillation incidence and mortality, and anesthetized rat heart coronary ligation - The incidence of reperfusion ventricular tachycardia and ventricular fibrillation. The anti-arrhythmic effect of TPGFA is stronger than that of A-TP. TPG-FA significantly prolonged the QTc interval of electrocardiogram, but had no obvious effect on the P-R interval and QRS duration. The LD50 of mouse ivTPGFA was 42 mg · kg -1.