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在几种动物模型上观察了四丙酰关附醇胺(TPGFA)的抗心律失常作用.TPGFA使引发室性早搏,室性心动过速和心室纤颤所需乌头碱用量增加50%的剂量分别为1.6,1.4FK和1.8mg·kg-1;TPGFA2mg·kg-1可提高豚鼠心脏毒毛花苷G中毒的耐受量和家兔心脏电致室颤阈;TPGFA还降低Ca-Cl2诱发的大鼠室颤发生率和死亡率,以及麻醉大鼠心脏冠脉结扎—再灌性室性心动过速和室颤的发生率.TPGFA的上述抗心律失常作用较关附甲素强.TPG-FA显著延长大鼠心电图的QTc间期,而对P-R间期和QRS时程影响不明显.小鼠ivTPGFA的LD50为42mg·kg-1.
The anti-arrhythmic effects of tetrapropionyl-ethanolamine (TPGFA) were observed on several animal models. The doses of TPGFA that increased 50% of the aconitine required for premature ventricular premature ventricular tachycardia, ventricular tachycardia and ventricular fibrillation were 1.6, 1.4FK and 1.8 mg · kg-1, respectively. TPGFA 2 mg · kg -1 Can increase the tolerance of guinea pig heart glycosides G poisoning and rabbit cardiac electrical ventricular fibrillation threshold; TPGFA also reduces the Ca-Cl2 induced rat ventricular fibrillation incidence and mortality, and anesthetized rat heart coronary ligation - The incidence of reperfusion ventricular tachycardia and ventricular fibrillation. The anti-arrhythmic effect of TPGFA is stronger than that of A-TP. TPG-FA significantly prolonged the QTc interval of electrocardiogram, but had no obvious effect on the P-R interval and QRS duration. The LD50 of mouse ivTPGFA was 42 mg · kg -1.