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利用流体的惯性效应实现刚性微球的高通量精确操控是一种新颖微流控方法,其在材料合成、生化反应和医学诊断等领域有着重要应用。本研究为实现刚性微球的等间距聚焦流动,设计制备了基于惯性聚焦的具有多个聚焦单元和鞘液聚焦结构的微流控芯片,实验以直径10μm的聚苯乙烯微球作为模型,考察了在特定微流条件下微球的聚焦效果。结果表明,在乙醇样品液以710μL/min流量均匀流动时,微球自第60个聚焦单元开始聚焦形成单一排列的流型。在已稳定聚焦成单一排列的微球队列上叠加相应条件的鞘液聚焦流,能够增强流动聚焦效果,并可控制微球间的相对距离。上述结果为深入研究微流体环境下刚性粒子的运动特性和开发相关的微流芯片提供了重要参考。
It is a novel microfluidic method to realize high-throughput precise control of rigid microspheres by utilizing the inertial effect of fluid. It has important applications in the fields of material synthesis, biochemical reaction and medical diagnosis. In order to realize the equal-pitch focusing flow of rigid microspheres, a microfluidic chip with multiple focusing elements and sheath-fluid focusing structures based on inertial focusing was designed and fabricated. The microspheres with a diameter of 10 μm were used as the model to investigate The focusing effect of microspheres under specific microfluidic conditions. The results showed that when the ethanol sample flowed uniformly at 710μL / min, the microspheres began to focus from the 60th focusing unit to form a single flow pattern. Superposition of the appropriate conditions of the sheath fluid focused stream on a uniformly aligned array of microspheres stabilizes the flow focusing effect and controls the relative distance between the microspheres. The above results provide an important reference for the further study of the movement characteristics of rigid particles in microfluidic environment and the development of related microfluidic chips.