胎儿肢体畸形发生率约1/500[1],是常见的胎儿畸形之一,它的病因主要为遗传因素(包括基因突变、染色体异常)和非遗传因素(如孕早期感染风疹病毒,接受X射线照射及某些药物的影响)。这些疾病有许多是在出生后或在生长发育过程中表现出来或需经X射线及化验室检查才能确诊的畸形[2] Fetal limb deformity incidence rate of about 1/500 [1], is one of the common fetal malformations, which are mainly due to genetic causes (including genetic mutations, chromosomal abnormalities) and non-genetic factors (such as early pregnancy rubella virus infection, to accept X Ray exposure and the effects of certain drugs). Many of these diseases are deformities that are either diagnosed after birth or during growth and development or confirmed by X-rays and laboratory tests [2]