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珍菊降压片中盐酸可乐宁及双氢氯噻嗪含量测定方法鉴定会由上海医药工业研究院、上海市药材公司主持,于1980年1月15日在上海医药研究院召开。珍菊降压片是上海中药三厂生产的降压新药,由盐酸可乐宁、双氢氯噻嗪、芦丁、野菊花膏粉及珍珠层粉等组成,具有较好的降压和改善症状的作用。为了进一步保证药品质量,确保用药安全、有效,上海中药三厂提请上海医药工业研究院共同协作,寻找出一种能在大量中药存在下测定盐酸可乐宁及双氢氯噻嗪含量的方法。盐酸可乐宁的含量测定法为先加碱使可乐宁游离,用氯仿提取,经碱洗除去杂质后,再用 pH4枸橼酸缓
Jane Ju antihypertensive tablets clonidine hydrochloride and hydrochlorothiazide determination of content identification method by the Shanghai Institute of Pharmaceutical Industry, Shanghai herbs company presided over the January 15, 1980 in Shanghai Institute of Pharmaceutical Industry was held. Zhenju Antihypertensive tablets is a new antihypertensive drug produced by the Third Factory of Shanghai Traditional Chinese Medicine. It is composed of Clonidine Hydrochloride, Dihydrochlorothiazide, Rutin, Chrysanthemum Flower Powder and Nacreous Powder. It has good antihypertensive and ameliorating symptoms. In order to further ensure the quality of medicines and ensure safe and effective drug use, Shanghai Traditional Chinese Medicine Factory3 invited Shanghai Institute of Pharmaceutical Industry to work together to find out a method for the determination of clonidine hydrochloride and hydrochlorothiazide in the presence of a large amount of traditional Chinese medicine. Determination of clonidine hydrochloride content for the first alkali to make Clonidine free, extracted with chloroform, alkali to remove impurities, and then pH4 citrate slow