η-生育酚(η-Tocopherol)系从大米中分离出的天然化合物,是维生素E的异构体,是重要的天然抗氧化剂之一。Mchal等首先报道η-生育酚的合成,是以1,4-苯二酚为原料,先溴化得5-溴-2甲基-1,4苯二酚,经甲基化得二甲醚衍生物,然后制成的格氏试剂与环氧乙烷反应得5-(2-羟基)-2-甲基-1,4-苯 η-Tocopherol (η-Tocopherol) isolated from rice natural compounds, vitamin E isomers, is one of the important natural antioxidants. Mchal et al. First reported the synthesis of η-tocopherol, based on 1,4-benzenediol as the raw material, brominated to give 5-bromo-2-methyl-1,4-benzenediol, methylated to dimethyl ether Derivatives, which are then reacted with ethylene oxide to give 5- (2-hydroxy) -2-methyl-1,4-benzene