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本文利用2.2 kb人载脂蛋白A Ⅰ基因探针,检测河南省商丘地区冠心病患者及健康对照成人的载脂蛋白A Ⅰ—C Ⅲ基因区域Sst Ⅰ限制性片段长度多态性。发现Sst Ⅰ多态性位点与冠心病无密切关系,不宜作为该地区冠心病患者的遗传标记。
In this study, a 2.2 kb human apolipoprotein A Ⅰ gene probe was used to detect the Sst Ⅰ restriction fragment length polymorphism of the apolipoprotein A Ⅰ-C Ⅲ gene in CHD patients and healthy controls in Henan Province. Found that Sst Ⅰ polymorphism loci and coronary heart disease is not closely related, should not be used as genetic markers in patients with coronary heart disease in the region.