甲状腺毒症患者在甲状腺次全切除后,甲状腺机能减退症(甲减)的发生率取决于许多因素,包括残留的甲状腺的大小、腺体淋巴细胞浸润程度、血清内与补体结合的甲状腺抗体的存在,随访时间长短,以及某些患者自然进展为甲减等。随访发现,在心得安应用下,甲状腺毒症患者在术后头数月有临床和生化证据的甲减并非罕见,但大多数仅属暂时性。本文报告此类患者术后血清总甲状腺素(T_4)、三碘甲状腺原氨酸(T_3)和促甲状腺激素(TSH)的浓度。患者40例,在心得安应用下行甲状腺次全切除术。其中14例(35％)于术后2～3月发生临床轻度甲减,T_4、T_3降低,TSH升高。14例中10例甲减为暂时性。术后6个月,临床及生化资料证实甲状腺功能已恢复正常,T_4和T_3浓度在正常范围。10例中9例TSH于术后3个月时最高为27～282毫单位/升(正常上限为5.7毫单位/升),而在6个月时均降低,但均未降至正常。另4例术后甲减者,6个月后甲状腺功能未恢复。40例中26例临床上甲状腺功 The incidence of hypothyroidism (hypothyroidism) in thyrotoxic patients following subtotal thyroidectomy depends on many factors, including the size of the residual thyroid gland, the degree of glandular lymphocyte infiltration, the amount of thyroid antibodies bound to complement in the serum Exist, the length of follow-up, and some patients with natural progression hypothyroidism and so on. Follow-up found that in the application of empathy, thyrotoxicosis patients with clinical and biochemical evidence of hypothyroidism in the first few months after surgery is not uncommon, but most are only temporary. This article reports the serum total thyroxine (T_4), triiodothyronine (T_3) and thyroid stimulating hormone (TSH) concentrations in these patients. 40 cases of patients, the application of descending thyroid in sub-total thyroidectomy. Among them, 14 cases (35%) had mild hypothyroidism, T_4 and T_3 decreased and TSH increased in 2 ~ 3 months after operation. 10 cases of hypothyroidism were transient in 14 cases. After 6 months, the clinical and biochemical data confirmed that thyroid function has returned to normal, T_4 and T_3 concentrations in the normal range. The TSHs of 9 patients in 9 of the 10 patients were 27-282 milliunits / liter at the highest of 3 months after operation (upper limit of normal was 5.7 milliwatts / liter), but decreased at 6 months but none of them dropped to normal. The other 4 cases of hypothyroidism, thyroid function did not recover after 6 months. Twenty-six of 40 cases had clinical thyroid function