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目的 探讨高血压家族史 (HPHIS)阳性人群与糖尿病患病的关系。方法 对我国 19个省市 2 5岁以上的 2 5万人糖尿病普查中 15 2 2 4人按有无HPHIS分成阳性和阴性组 ,按 1997年美国ADA标准分为正常人 (NGT)、糖耐量低减 (IGT)、糖尿病 ,进行组间比较及多因素回归分析。结果(1)HPHIS阳性组与阴性组比较年龄、BMI、WHR、血糖、血压显著增高 (P <0 0 0 0 1) ,但两组糖尿病家族史 (DMHIS)差异无显著性。 (2 )总体人群分成正常人、IGT、糖尿病后HPHIS阳性率 (分别为13 86 % ,19 5 8% ,2 9 2 0 % )比较差异有显著性 (P <0 0 0 1)。 (3)对正常人和IGT或糖尿病人群进行多因素回归分析 ,HPHIS也与IGT或糖尿病的发生呈独立正相关。结论 (1)HPHIS阳性人群的BMI、WHR、血压、血糖水平均显著高于阴性组。 (2 )HPHIS阳性与糖尿病、IGT的发生呈独立正相关 ,提示HPHIS阳性是糖尿病的重要发病危险因素之一
Objective To investigate the relationship between family history of hypertension (HPHIS) and diabetes mellitus. Methods Fifteen of 22 500 people aged 25 years and older in 19 provinces and cities in China were divided into positive and negative groups according to the presence or absence of HPHIS. According to the American ADA standard in 1997, they were divided into normal (NGT), glucose tolerance (IGT), diabetes mellitus, compared between groups and multivariate regression analysis. Results (1) The age, BMI, WHR, blood glucose and blood pressure in HPHIS positive group were significantly higher than those in negative group (P <0.01 01). However, there was no significant difference in DMHIS between the two groups. (2) There was significant difference (P <0.01) in the positive rate of HPHIS among the general population divided into normal, IGT and post-diabetes (13 86%, 19 58%, 29 02% respectively). (3) Multivariate regression analysis of normal and IGT or diabetic population showed that HPHIS was also independently and positively correlated with IGT or diabetes. Conclusions (1) The BMI, WHR, blood pressure and blood glucose in HPHIS positive group were significantly higher than those in the negative group. (2) HPHIS positive and diabetes, IGT were independently and positively correlated, suggesting that HPHIS positive is one of the important risk factors for diabetes