粘蛋白1(MUC1)是一种跨膜糖蛋白,正常情况下表达于多种组织、器官上皮细胞近管腔或腺腔面,呈极性分布。研究发现MUC1在70%以上的实体瘤中异常表达,并与肿瘤的发生、发展和转移密切相关。本文综述了肿瘤相关的信号通路,包括Wnt信号通路、酪氨酸激酶通路及细胞核内转录因子等信号通路中,MUC1的影响和功能,提示MUC1是细胞信号网络整合的桥梁和平台。 Mucin 1 (MUC1) is a transmembrane glycoprotein, which is normally expressed in a variety of tissues and organs, near the lumen or glandular surface, with a polar distribution. The study found that MUC1 is abnormally expressed in more than 70% of solid tumors and is closely related to tumorigenesis, development and metastasis. This review summarizes the effects and functions of MUC1 in tumor-related signaling pathways, including Wnt signaling pathway, tyrosine kinase pathway and nuclear transcription factor signaling pathway, suggesting that MUC1 is a bridge and platform for cell signaling network integration.