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目的：观察兔激素性股骨头缺血性坏死骨质中SREBP-1c及PPARγ的表达。方法：使用醋酸泼尼松龙制备兔激素性股骨头缺血性坏死动物模型，采用实时荧光定量PCR 检测PPARγ、SREBP-1c在骨组织中的表达情况。结果：PPARγ、SREBP-1c的表达量在骨组织中较正常组织中显著增多（P＜0.05）；实验组中PPARγ表达量比SREBP-1c mRNA 显著增多（P＜0.05）。结论：SREBP-1c及PPARγ的信号转导途径影响脂肪细胞的分化，其在兔激素性股骨头坏死脂质代谢中发挥重要的作用。“,”Objective To observe the expression of SREBP-1 c and PPARγin Rabbit glucocorticoid-induced avascular necrosis. Methods Prednisolone acetate was used to establish the animal model of rabbit glucocorticoid-induced avascular necrosis, and the expression of SREBP-1 c and PPARγin bone tissue were detected by real-time fluorescent quantitative PCR assay. Results The expression of PPARγmRNA in bone tissue were higher than normal tissue (P<0.05);The expression of PPARγwas higher than in the SREBP-1c in the experimental group (P<0.05). Conclusion Signal transduction pathway of SREBP-1c and PPARγplay an important role in glucocorticoid induced avascular necrosis lipid metabolism by effecting fat differentiation.