胃癌的基因治疗作为一种新的治疗手段 ,近年倍受重视 ,在动物实验中取得了可喜的成果。胃癌发病的分子基础是设计基因治疗靶点的依据。胃癌基因治疗的研究主要集中在以下方面 :抑癌基因基因治疗、“自杀”基因基因治疗、反义基因治疗、核酶基因转染治疗、基因免疫治疗等。本文就这些方面的进展作一概述。 As a new treatment method, gene therapy of gastric cancer has drawn great attention in recent years and has achieved gratifying results in animal experiments. The molecular basis of the pathogenesis of gastric cancer is the basis for designing gene therapy targets. Gene therapy of gastric cancer mainly focuses on the following aspects: gene therapy of tumor suppressor gene, gene therapy of suicide gene, antisense gene therapy, transfection of ribozyme gene therapy and gene immunotherapy. This article gives an overview of progress in these areas.