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采用小剂量(2μg)按0、1、6免疫程序皮内接种乙型肝炎疫苗,分别于首次接种后的第1,3,7,18,36个月进行免疫学效果的动态观察,证明不同月份抗—HB_g阳转率,不同月份抗—HB_g浓度和抗—HB_g浓度≥10mIu/ml者所占比例,三项指标与对照组(常规剂量10μg肌肉注射)之间无显著性差异,提示小剂量皮内接种法可望代替常规剂量增接种法。
A small dose (2μg) of hepatitis B vaccine was intradermally administered according to the 0,1,6 immunization program, and the dynamic observation of immunological effects was performed on the 1st, 3rd, 7th, 18th and 36th month after the first vaccination, There was no significant difference between the three indexes and the control group (the conventional dose of 10μg intramuscular injection) in the month of anti-HBg positive rate, anti-HB_g concentration in different months and anti-HB_g concentration ≥10mIu / ml, suggesting that small Dose intradermal inoculation method is expected to replace conventional dose-adding method.