论文部分内容阅读
目的研究道地产区磐安延胡索Corydalis Rhizoma的化学成分。方法采用硅胶、Sephadex LH-20等柱色谱方法进行分离纯化,通过化合物的理化性质和谱学数据鉴定其结构。结果从延胡索95%乙醇提取物中分离得到20个生物碱,分别鉴定为左旋四氢黄连碱(1)、四氢非洲防己胺(2)、延胡索乙素(3)、紫堇球碱(4)、异紫堇球碱(5)、8-三氯甲基-7,8-二氢黄连碱(6)、延胡索甲素(紫堇碱,7)、8-酮基黄连碱(8)、左旋紫堇根碱(9)、去氢延胡索甲素(10)、13-甲基巴马亭红碱(11)、氧化海罂粟碱(12)、原阿片碱(13)、降氧化北美黄连次碱(14)、四氢小檗碱(15)、二去氢海罂粟碱(16)、黄海罂粟灵碱(17)、黄连碱(18)、巴马亭(19)、小檗碱(20)。结论化合物6、9和16均为首次从延胡索中分离得到。首次应用2D NMR技术对化合物6和16的13C-NMR、1H-NMR信号进行了全归属。
Objective To study the chemical constituents of Corydalis Rhizoma in Panzhiqu, a real estate area. Methods The compounds were separated and purified by column chromatography on silica gel and Sephadex LH-20. Their structures were elucidated by their physicochemical properties and spectral data. RESULTS: Twenty alkaloids were isolated from 95% ethanol extract of Corydalis yanhusuo and identified as levomethorphan base (1), tetrandrine (2), tetrahydropalmatine (3) and cortisone (4 (5), 8-trichloromethyl-7,8-dihydropiperhin (6), fusidin A (corydaline, 7) , Rhodopsin (9), Hydrotalcobarbin (10), 13-Methyl Palmitine (11), Oxymethrin (12), Protopine (13) Keywords berberine (14), tetrahydroberberine (15), dihydrogenated papaverine (16), yellow poppy base (17), berberine (18), palmatine (19), berberine (20). Conclusion Compounds 6, 9 and 16 were isolated from corydalis for the first time. For the first time, 13C-NMR and 1H-NMR signals of compounds 6 and 16 were completely assigned by 2D NMR.