30年前研究发现,早产儿尤其是极低出生体重儿患代谢性骨病、身高增长延缓、佝偻病的风险增高。随着新生儿重症监护技术的发展,上述情况发生率持续升高。最近报道55%出生体重<1000 g和23%出生体重<1500 g的早产儿骨矿化不足。约80%的骨矿物质储存发生在胎儿宫内发育的最后3个月,先天储存不足使早产儿发生代谢性骨病 Thirty years ago, the study found that premature children, especially those with very low birth weight, had metabolic bone disease, increased height retardation, and increased risk of rickets. With the development of neonatal intensive care technology, the incidence of these conditions continues to rise. Recently, 55% of premature infants with birth weight <1000 g and 23% of birth weight <1500 g have reported bone mineralization. About 80% of bone mineral stores occur during the last 3 months of intrauterine development, and congenital storage deficits cause metabolic bone disease in preterm infants