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目的:研究阿奇霉素对肺炎支原体肺炎患儿免疫功能的影响。方法:选择2012年1月-2013年12月在我院治疗的110例肺炎支原体肺炎患儿为研究对象,随机分为实验组、对照组各55例。实验组予阿奇霉素,对照组予红霉素,5天一疗程,14天后比较两组治疗效果、Ig A、Ig G、Ig M水平和T淋巴细胞亚群。结果:实验组治疗有效率94.55%,明显高于对照组的81.82%;治疗后,两组Ig A、Ig G、Ig M均低于治疗前,CD4+和NK细胞含量下降,CD8+含量明显升高,CD4+/CD8+明显降低,实验组CD4+、NK细胞、CD4+/CD8+为(38.16±7.18)%、(10.12±4.28)%、(1.13±0.33),明显低于对照组的(43.28±6.24)%、(15.25±4.18)%、(1.57±0.29),CD8+含量为(30.03±8.59)%,明显高于对照组的(25.11±8.31)%,P<0.05时,差异有统计学意义。结论:阿奇霉素治疗肺炎支原体肺炎疗效显著,能够有效调节免疫功能的作用,建议在临床上推广应用。
Objective: To study the influence of azithromycin on immune function in children with Mycoplasma pneumoniae pneumonia. Methods: One hundred and ten children with Mycoplasma pneumoniae pneumonia treated in our hospital from January 2012 to December 2013 were selected as study subjects and randomly divided into experimental group and control group with 55 cases each. The experimental group received azithromycin and the control group received erythromycin for 5 days for one course of treatment. The therapeutic effects, levels of Ig A, Ig G, Ig M and T lymphocyte subsets were compared between the two groups after 14 days. Results: The effective rate of the experimental group was 94.55%, which was significantly higher than that of the control group (81.82%). After treatment, the levels of Ig A, Ig G and Ig M in both groups were lower than those before treatment, while the contents of CD4 + and NK cells decreased and the content of CD8 + (38.16 ± 7.18)%, (10.12 ± 4.28)% and (1.13 ± 0.33) respectively in the experimental group were significantly lower than those in the control group (43.28 ± 6.24)% and CD4 + / CD8 + , (15.25 ± 4.18)%, (1.57 ± 0.29) and CD8 + (30.03 ± 8.59)%, respectively, which was significantly higher than that of the control group (25.11 ± 8.31)%, and the difference was statistically significant at P <0.05. Conclusion: Azithromycin treatment of mycoplasma pneumoniae significant effect, can effectively regulate the role of immune function, it is recommended to promote the clinical application.