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目的：探讨细胞信号传导分子Ｐ３６与肝细胞癌发生、发展的关系。方法：采用ＳＰ免疫细胞化学方法，检测７０例肝细胞癌组织中Ｐ３６的分布和表达。结果：４０例Ｐ３６表达阳性，占５７．１％，阳性物质主要位于胞浆内，少数位于胞核或胞膜上。肿瘤分化越差，其阳性染色越强。Ｐ３６在ＨＢｘＡｇ阳性病例中的检出率高于ＨＢｘＡｇ阴性病例中的检出率（Ｐ＜０．０５）。结论：Ｐ３６有可能成为判定肝细胞癌恶性程度的标记物，Ｐ３６的异常表达与肝细胞癌的发生、发展关系密切，并可能与ＨＢＶ感染有关
Objective: To investigate the relationship between cell signal transduction molecule P36 and the occurrence and development of hepatocellular carcinoma. METHODS: SP immunocytochemistry was used to detect the distribution and expression of P36 in 70 cases of hepatocellular carcinoma. Results: The expression of P36 was positive in 40 cases, accounting for 57.1%. The positive substance was mainly in the cytoplasm and a few in the nucleus or membrane. The worse the tumor differentiation, the stronger the positive staining. The detection rate of P36 in HBxAg-positive cases was higher than that in HBxAg-negative cases (P<0.05). Conclusion: P36 may be a marker for judging the malignant degree of hepatocellular carcinoma. The abnormal expression of P36 is closely related to the occurrence and development of hepatocellular carcinoma, and may be related to HBV infection.