用11％醋酸在68℃,条件下处理肝素钙,当肝素钠盐和钙盐分子中约25％的N-硫释放出来,相应的有25％的氨基暴露,肝素钠盐的抗凝血活性完全消失,肝素钙盐则失活约75％。相同条件下肝素纳盐和钙盐净化脂性血浆的活性不受酸水解的影响,由此提供了一个简易制备改构肝素的方法 Heparin calcium was treated with 11% acetic acid at 68 ° C, and about 25% N-sulfide was released from the heparin sodium and calcium salt molecules, with a corresponding 25% amino exposure, anticoagulant activity of the heparin sodium salt Completely disappear, heparin calcium is about 75% inactivated. Under the same conditions heparin sodium salt and calcium salt purify the activity of the lipid plasma is not affected by acid hydrolysis, thus providing a simple preparation of modified heparin method