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目的分析机械通气联合吸入一氧化氮对新生儿重度呼吸衰竭呼吸功能指标及动脉血气指标的影响。方法选取漯河医学高等专科学校2012年3月—2016年8月收治的72例新生儿重度呼吸衰竭患儿,采用随机数字表法分为观察组(n=36)和对照组(n=36),两组均给予机械通气治疗,观察组加用一氧化氮吸入治疗,对比两组治疗前和治疗24h后呼吸功能指标[氧合指数(OI)、吸气氧浓度分数(FiO_2)、平均气道压(MAP)、动脉肺泡氧分压比值(a/A)]、动脉血气指标[动脉血氧分压(PaO_2)、动脉血二氧化碳分压(PaCO_2)]。结果观察组治疗24h后OI、FiO_2、MAP、a/A与对照组相比,显著降低,差异具有统计学意义(P<0.05);观察组治疗24h后PaO_2高于对照组,PaCO_2低于对照组,差异具有统计学意义(P<0.05)。结论新生儿重度呼吸衰竭以机械通气联合吸入一氧化氮治疗,可显著改善患儿呼吸功能和动脉血气状态,推广价值较高。
Objective To analyze the effects of mechanical ventilation and inhalation of nitric oxide on respiratory function and arterial blood gas index in neonates with severe respiratory failure. Methods 72 neonates with severe respiratory failure who were admitted to Luohe Medical College from March 2012 to August 2016 were randomly divided into observation group (n = 36) and control group (n = 36) , Both groups were given mechanical ventilation treatment, the observation group plus nitric oxide inhalation treatment, before and after treatment compared the two groups of respiratory function indicators [oxygenation index (OI), inspiratory oxygen concentration (FiO_2), mean gas MAP, a / A), arterial blood gas index (PaO_2) and arterial carbon dioxide (PaCO_2). Results Compared with the control group, the OI, FiO_2, MAP and a / A in the observation group were significantly lower than those in the control group (P <0.05); PaO_2 in the observation group was higher than that in the control group 24h after treatment, PaCO_2 was lower than the control group Group, the difference was statistically significant (P <0.05). Conclusion Neonatal severe respiratory failure with mechanical ventilation combined with nitric oxide treatment can significantly improve children’s respiratory function and arterial blood gas status, the promotion of higher value.