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目的探讨血清胰岛素样因子1(IGF-1)和一氧化氮(NO)对原发性高血压(EH)患者发生左室肥厚(LHV)的影响。法对大连大学附属医院2008年的35例患者(EH组)和25例正常人(正常对照组)用特异性放射免疫法测定IGF-1浓度,用硝酸盐还原法测定NO浓度。结果EH组IGF-1浓度明显高于25例对照组(14.11±2.46nmol/l Vs10.77±3.27nmol/l,p<0.05),EH组NO浓度明显低于对照组(70.15±15.08umol/l Vs79.35±17.10umol/l,p<0.05);EH并发LVH患者IGF-1浓度明显高于无LVH患者(15.05±3.73nmol/l Vs10.97±4.01nmol/l,p<0.01),而NO浓度低于无LVH患者(55.80±15.35umol/l Vs69.38±17.87umol/l,p<0.05)。结论EH患者IGF-1浓度明显升高,而NO浓度降低,尤其是并发LVH者。IGF-1和NO两者失衡可能参与EH及并发LVH的发生。
Objective To investigate the effects of serum insulin-like factor 1 (IGF-1) and nitric oxide (NO) on left ventricular hypertrophy (LHV) in patients with essential hypertension (EH). The method of specific radioimmunoassay was used to determine the concentration of IGF-1 in 35 patients (EH group) and 25 normal persons (normal control group) of Affiliated Hospital of Dalian University in 2008, and the NO concentration was determined by nitrate reduction method. Results The concentration of IGF-1 in EH group was significantly higher than that in control group (14.11 ± 2.46nmol / l Vs10.77 ± 3.27nmol / l, p <0.05), and the NO concentration in EH group was significantly lower than that in control group (70.15 ± 15.08umol / (P <0.05). The IGF-1 levels in patients with EH complicated with LVH were significantly higher than those without LVH (15.05 ± 3.73nmol / l, Vs10.97 ± 4.01nmol / l, p <0.01) While the NO concentration was lower in patients without LVH (55.80 ± 15.35umol / l Vs69.38 ± 17.87umol / l, p <0.05). Conclusion EH patients with IGF-1 concentration was significantly increased, while the NO concentration decreased, especially in patients with LVH. The imbalance between IGF-1 and NO may be involved in the occurrence of EH and concurrent LVH.