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目的:主要研究黄芪颗粒对急性发作期哮喘病儿临床疗效、外周血淋巴细胞及细胞因子水平的影响.方法:将急性发作期哮喘病儿随机分成治疗组和对照组,治疗组哮喘病儿在给予常规治疗的基础上加服黄芪颗粒,对照组采用单纯西药治疗.检测治疗前、后病儿外周血CD4、CD8、白细胞介素4(IL-4)和白细胞介素12(IL-12)水平.结果:治疗组总有效率明显高于对照组.治疗后治疗组与对照组比较CD4+上升,CD8+下降,CD4+/CD8+升高(P0.05).结论:黄芪颗粒能有效调节哮喘患儿T细胞亚群和细胞因子,较好的辅助治疗小儿哮喘.“,”To investigate the clinical efficacy and effect of radix astragali particles on peripheral blood lymphocytes and cytokines in children with acute exacerbation asthma. Methods: The children with acute exacerbation asthma were randomly divided into two groups: treatment group were treated with conventional therapy and radix astragali particles, while control group were treated with Western medicine only. The levels of CD4, CD8, IL-4 and IL-12 were detected before and after treatment. Results: The total effective rate in treatment group was significantly higher than that in control group. After treatment, compared to control group, the level of CD4+ and CD4+ /CD8+ ratio increased, the level of CD8+decreased in treatment group (P0. 05) . Conclusion: Radix astragali particles can regulate T cell subsets and cytokines, which is a good adjunctive therapy for children with asthma.