常染色体显性遗传的多囊肾患者可出现顽固性腹痛或腰痛,某些病人需用麻醉剂方能部分缓解。疼痛与部分肾单元进行性囊性扩张所致的腺肿大有关,在肾功能损害尚不明显时即可发生。1911年Rovsing首先以减囊术缓解病人的疼痛,其他作者亦相继证实该手术之疗效。但从五十年代末及六十年代初以来,减囊术被废弃。其主要原因是1957年Bricker和Patton报告作减囊术后病人的肾功能在一年内下降,推断是由于功能性肾单元的手术损失;1963年Milam和同事也有类似报告。但是事实上两文均仅报告2例病人,而且手术前的肾功能下降情况均未指出。理论上说即使手术中丧失几百个肾单元,对总肾小球滤过率没有什么影响。如果肾衰是由于囊肿压迫正常肾单元所致,那么减少囊肿的体积可保存肾功 Autosomal dominant polycystic kidney disease patients may have stubborn abdominal pain or back pain, some patients need anesthesia to be partially relieved. Pain and some of the renal cell cystic expansion due to enlargement of the gland, renal damage can not occur when the obvious. Rovsing first in 1911 to reduce the patient’s sore capsule relief, other authors have also confirmed the efficacy of the operation. However, the sachet has been abandoned since the late fifties and early sixties. The main reason for this is that the renal function of the patient decreased after one year as reported by Bricker and Patton in 1957 as a result of a decrease in one year, presumably due to the surgical loss of a functional nephron; similarly reported by Milam and colleagues in 1963. However, in fact, only two patients were reported in both languages, and the decline of renal function before surgery was not indicated. Theoretically, even if hundreds of nephrons are lost during surgery, there is no effect on the total glomerular filtration rate. If renal failure is due to cyst compression normal nephron, then reduce the volume of cysts can save kidney function