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芪(二苯乙烯)通常用于化学工业,对其药理活性的研究很少。通过动物实验我们发现芪能明显保护CCl_4引起的小鼠肝损害,表现在使高的SGPT及SGOT降低、BSP潴留减少、肝组织病变减轻等。芪明显促进肝糖元生成,此作用强度与可的松相近,但芪没有可的松那样的抗炎作用。在去肾上腺小鼠,芪仍能明显促进肝糖元生成,故此作用似乎不通过体内的垂体-肾上腺系统。芪对小鼠戊巴比妥睡眠时间影响不明显。根据实验资料分析,芪对CCl_4肝损害的保护机制大概不是通过酶诱导,也不象某些抗氧化剂那样直接对抗CCl_4的作用,但有可能与其促进肝糖元生成有某种关系。 芪有微弱的雌激素作用(约为己烯雌酚的数万分之一)。 芪的毒性很低,小鼠一次腹腔注射LD_(50)为6.5 g/kg,灌胃LD_(50)大于8 g/kg,但油溶液毒性较大(灌胃LD_(50)为0.92g/kg)。长期大量给予芪,对雄小鼠的生长及睾丸发育有抑制作用,给狗服芪50 mg/kg/天连续一个月以上未见明显异常反应。
Astragalosides (stilbenes) are commonly used in the chemical industry and little is known about their pharmacological activity. Through animal experiments we found that stilbene can significantly protect liver damage caused by CCl 4 mice, manifested in the high SGPT and SGOT decreased, BSP retention decreased, lessened liver tissue lesions. Qi significantly promote glycogen production, similar to cortisone and its intensity, but there is no anti-inflammatory effect of cortisone. In adrenal mice, stilbene can still significantly promote hepatic glycogen production, so the effect does not seem to pass the body’s pituitary-adrenal system. Qi on mouse pentobarbital sleep time is not obvious. According to the experimental data analysis, the protective mechanism of stilbene on CCl4 liver damage is probably not through the induction of enzymes, nor as some anti-oxidants directly against the role of CCl 4, but it may have a relationship with the promotion of hepatic glycogen. Qi weak estrogen effect (about one-thousandth of diethylstilbestrol). The toxicity of stilbene was very low. The intraperitoneal injection of LD_ (50) was 6.5 g / kg and the LD_ (50) of the mice was more than 8 g / kg. However, the toxicity of the oily solution was relatively high kg). Long-term large doses of stilbene, male mice growth and testicular growth inhibition, giving dog service stilbene 50 mg / kg / day for more than a month without significant abnormal response.