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目的:探讨辛伐他汀对男性高脂血症合并高尿酸血症患者血尿酸的影响,以及尿酸水平与颈动脉内膜中层厚度(IMT)的关系。方法:将98例男性高脂血症合并高尿酸血症患者分两组治疗,治疗组及对照组均行低脂低嘌呤饮食及甘糖酯100mg,3次/d降脂治疗,治疗组加服辛伐他汀20mg,睡前1次,疗程均为12周;根据治疗前颈动脉超声结果分为正常组、IMT增厚组和斑块组,比较各组血尿酸变化。结果:与对照组治疗后比较,治疗组血尿酸明显降低(P<0.01);颈动脉IMT随血尿酸水平升高而增厚(P<0.01)。结论:高尿酸血症是动脉粥样硬化的危险因素,辛伐他汀可降低其血尿酸水平。
Objective: To investigate the effect of simvastatin on serum uric acid in male patients with hyperlipidemia and hyperuricemia, and the relationship between uric acid and carotid intima-media thickness (IMT). Methods: 98 cases of male hyperlipidemia patients with hyperuricemia were divided into two groups, the treatment group and the control group were treated with low-fat and low-purine diet and 100 mg of sugar ester, 3 times / d lipid-lowering treatment, the treatment group Serum simvastatin 20mg, 1 times before going to bed, the course of treatment was 12 weeks. According to the result of carotid artery ultrasound before treatment, it was divided into normal group, IMT thickening group and plaque group. Results: Compared with the control group, serum uric acid of the treatment group was significantly decreased (P <0.01). The IMT of the carotid artery was increased with the increase of serum uric acid level (P <0.01). Conclusion: Hyperuricemia is a risk factor for atherosclerosis, simvastatin can reduce the level of serum uric acid.