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在临床上我们发现乙胺碘呋酮的副作用甚多,其发生率可高达50%,有些副作用甚至是致死性的,应引起临床重视。本文从临床用药角度,结合复习国内外文献,概述乙胺碘呋酮副作用的发生机制以及临床对策,探讨乙胺碘呋酮的临床应用注意事项及指征。一、心血管系统副作用1.乙胺碘呋酮的致心律失常作用:乙胺碘呋酮具有抑制窦房结和房室结、抑制房室传导、延长心房和心室肌的动作电位时间和有效不应期、抑制交感神经的作
Clinically, we found that many side effects of amiodarone, the incidence can be as high as 50%, some side effects or even fatal, should cause clinical attention. This article from the clinical drug point of view, combined with review of domestic and foreign literature, an overview of the mechanism of amiodarone side effects and clinical strategies to explore the clinical application of amiodarone attention and indications. First, the cardiovascular system side effects 1 amiodarone induced arrhythmia effect: Amiodarone with sinus node and atrioventricular node inhibition, inhibition of atrioventricular conduction and prolong the atrial and ventricular myocardial action potential time and effective Refractory, inhibit the production of sympathetic