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1992年爱尔兰患血友病甲的病人中爆发了甲型肝炎(HAV).在意大利、德国和比利时也报道了相同的爆发情况.本研究的目的是为了调查和检验这是由于暴露于溶媒净化处理的第Ⅷ因子引起爆发的这一假设.研究开始于1993年初,研究的人群是由爱尔兰血友病甲的病人中收集来的、通过人、地点、时间来分析爆发的原因.设计了一项病例对照研究.以查明血液制品和其它环境因素的作用.回答率(respnuserate)接近90%.29例患有急性甲肝的血友病甲病例与暴露于溶媒净化处理的第Ⅷ因子和其它环境因素的对照组78例血友病甲病人进行比较.血液制品的数据系从国家血友病登记处获得.环境资料则可从电话执行的调查表得到.在年轻病人和患有较重的血友病病人中,甲肝感染的发生率较高.接触肝炎、接触儿童以及暴露于
Hepatitis A (HAV) broke out in Ireland in patients with hemophilia A in 1992. The same outbreak was also reported in Italy, Germany and Belgium.The purpose of this study was to investigate and test this as a result of exposure to solvent cleanup The hypothesis that the treatment of factor VIII caused an outbreak began in early 1993 and the study population was collected from patients with hemophilia A. The cause of the outbreak was analyzed by person, place and time, Case-control study to determine the role of blood products and other environmental factors with a response rate of nearly 90% .29 cases of hemophilia A with acute hepatitis A and factor VIII exposed to solvent purification and others Environmental factors in the control group, 78 cases of hemophilia A patients were compared for blood products data obtained from the national hemophilia registry Environmental information can be obtained from the telephone implementation of the questionnaire in young patients and patients with severe Hemophilia patients have a higher prevalence of hepatitis A. Exposure to hepatitis, exposure to children and exposure to