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目的:对全球2016年至2021年乙型肝炎研究热点和趋势进行分析。方法:检索2016年1月1日至2021年11月22日Web of Science核心合集数据库中收录的乙型肝炎相关文献。利用InCites平台和VOSviewer 1.6.8可视化分析工具总结文献发表情况、高被引论文、全球核心研究国家/地区，并进行主题聚类，结合相关文献的具体内容进行阐述，分析研究热点。结果:截至2021年11月22日，共检索到12 299篇文献，2016年至2021年全球乙型肝炎相关研究文献发表数量分别为2 045篇、1 996篇、2 039篇、2 118篇、2 186篇和1 915篇。中国内地(大陆)是发文量最多的国家/地区(4 422篇，35.95%)，篇均被引频次为7.46，美国发文量排在第2位(1 949篇，15.85%)，篇均被引频次为13.78。关键词主题聚类后得到的主要研究方向为：乙型肝炎病毒(hepatitis B virus, HBV)感染及HBV与丙型肝炎病毒、人类免疫缺陷病毒等的重叠感染、原发性肝细胞癌、抗病毒治疗与乙型肝炎治愈、HBV病毒学、HBV与宿主免疫、HBV再激活、HBV疫苗等。结论:近6年全球乙型肝炎领域的研究集中于乙型肝炎流行病学及管理，乙型肝炎相关肝癌的预测与预防，乙型肝炎治愈与治疗优化，乙型肝炎发生、发展过程中HBV病毒学与宿主免疫机制等。全球乙型肝炎相关研究的文献发表数量相对平稳。中国内地(大陆)研究数量处于国际领先水平，但研究影响力尚需进一步扩大。“,”Objective:To analyze the hotspots and trends of global researches in the field of hepatitis B from 2016 to 2021.Methods:Based on the Web of Science Core Collection Database, the indexed “article” and “review” related to hepatitis B from January 1, 2016 to November 22, 2021 were collected. Using InCites and VOSviewer 1.6.8 to cluster the published features, highly cited papers, key research directions and subject headings.And combined with the specific content of the literature, a summary of research hotspots was formed and analyzed.Results:As of November 22, 2021, a total of 12 299 articles were retrieved. From 2016 to 2021, the numbers of global hepatitis B-related research publications were 2 045, 1 996, 2 039, 2 118, 2 186 and 1 915, respectively. China′s mainland published the most papers (4 422 pieces, 35.95%), with the average citation frequency of only 7.46, and the United States ranked second in terms of the number of papers published (1 949 pieces, 15.85%), with the average citation frequency of 13.78. The hotspots obtained after the clustering of keyword topics were hepatitis B virus (HBV) infection, coinfections of HBV and hepatitis C virus/human immunodeficiency virus, primary hepatocellular carcinoma, antiviral therapy and hepatitis B cure, HBV virology, HBV and immunology, HBV reactivation, HBV vaccine, etc.Conclusions:In the past six years, global researches in the field of hepatitis B have focused on hepatitis B epidemiology and management, prediction and prevention of hepatitis B-related liver cancer, hepatitis B cure and treatment optimization, HBV virology and host immune mechanism in the development of hepatitis B, etc.The number of published papers in the field of hepatitis B keeps relatively stable. The number of researches in China′s mainland is at the international leading level, but the influence of researches needs to be further improved.