本文着眼单克隆抗体(单抗)的临床应用,对当今人单抗研究进展概况、技术发展、新出现的问题及解决方案等进行文献复习。一、人单抗研究势在必行研究与制备单抗的主要目的之一在于临床应用单抗诊断与治疗人类疾病。目前,绝大多数单抗都是应用小鼠杂交瘤技术制备的鼠单抗。从临床角度看,人单抗优于鼠单抗。首先,不论诊断还是治疗,患者摄入的 This article focuses on the clinical application of monoclonal antibodies (mAb), literature review of the current status of MAb research progress, technological development, emerging issues and solutions. First, the study of human monoclonal antibody is imperative One of the main purposes of the study and preparation of monoclonal antibodies is the clinical application of monoclonal antibody diagnosis and treatment of human disease. At present, the vast majority of monoclonal antibodies are mouse monoclonal antibodies prepared using mouse hybridoma technology. From a clinical point of view, human monoclonal antibody is superior to the mouse monoclonal antibody. First of all, regardless of diagnosis or treatment, patients ingested