本文综述1981年日本国内发表的抗生素论文128篇和专利127份,不包括抗生素的纯化学、微生物和酶反应的研究。β-内酰胺类抗生素具有碳青霉烯骨架和有抑制β-内酰胺酶活性的第三代抗生素系列中(橄榄酸类、PS系列、地毯霉素(carpetimycins)、C-19393系列等)又增添了一种抗生素——asp-arenomycin A,该抗生素系由链霉菌(S.tokunonensis sp.nov)培养液中分离而得,对产生β-内酰胺酶的革兰氏阳性和阴性细 This review summarizes 128 articles and 127 patents on antibiotics published in Japan in 1981, excluding studies on pure chemistry, microorganisms and enzyme reactions of antibiotics. β-lactam antibiotics with carbapenem skeleton and β-lactamase inhibitory activity of the third generation of antibiotic series (olive, PS series, carpetomycin (carpetimycins), C-19393 series, etc.) Added an antibiotic, asp-arenomycin A, which is isolated from a culture of S. tokunonensis sp. Nov and produces a positive and a negative Gram-negative